A horse was killed on impact after it was hit by a vehicle along Highway 93.
The Twin Falls County Sheriff's Office says the crash occurred Friday morning between 3700 North and 3800 North. Police say the driver was heading north when the horse went onto the road.
The driver and the passenger were taken to the hospital with non-life threatening injuries.
"Please be cautious on our roads, things can change at any minute," police said. "Our prayers are with all involved."